Yentreve (Duloxetine) is used for treatment of urinary incontinence. Stress urinary incontinence (SUI), the most common form of urinary incontinence, is defined as the complaint of involuntary urine leakage upon effort or exertion, or on sneezing or coughing. Several risk factors or contributing variables to the development of SUI have been suggested over the last decade and include childbirth, obesity, pelvic organ prolapse or chronic coughing. Although common, SUI is a medical disorder that is not normal at any age. SUI may have a profound negative impact on the quality of life (QoL) of the affected individuals, leading to embarrassment and social isolation. Nonetheless, many women with bothersome symptoms of SUI do not seek appropriate medical attention because of the taboos around this disorder. Presently available treatment options include behavioral therapy, pelvic floor muscle training (PFMT) and surgery.

Clinical studies of duloxetine for the treatment of SUI have shown the most commonly reported adverse events (incidence of > 5 percent and at least twice the placebo rate) reported by patients receiving duloxetine have been nausea, dry mouth, fatigue, insomnia, constipation, headache, dizziness, somnolence (drowsiness) and diarrhea.

About Stress Urinary Incontinence SUI, the most common form of urinary incontinence, is defined as the complaint of involuntary urine leakage upon effort or exertion, or on sneezing or coughing.2 Several risk factors or contributing variables to the development of SUI have been suggested over the last decade and include childbirth, obesity, pelvic organ prolapse or chronic coughing.3 Although common, SUI is a medical disorder that is not normal at any age. SUI may have a profound negative impact on the quality of life (QoL) of the affected individuals, leading to embarrassment and social isolation. Nonetheless, many women with bothersome symptoms of SUI do not seek appropriate medical attention because of the taboos around this disorder. Presently available treatment options include behavioral therapy, pelvic floor muscle training (PFMT) and surgery.